Công dụng của lợi khuẩn lactobacillus trong y học

Trong ruột cơ thể con người có chứa khoảng 100.000 tỷ vi khuẩn gồm hơn 500 loài khác nhau, tạo thành một hệ cân bằng vi sinh đường ruột, trong đó có 85% là lợi khuẩn, 15% là hại khuẩn. Đôi khi, bệnh tật hoặc căng thẳng có thể thay đổi sự cân bằng của vi khuẩn và tạo ra các vấn đề về tiêu hóa và các vấn đề khác. Lợi khuẩn hoạt động bằng cách thay đổi thành phần của vi khuẩn đường ruột hoặc hoạt động trao đổi chất của vi khuẩn hiện có. Các vi khuẩn tốt lấn át hại khuẩn trong ruột. Điều này ngăn chặn vi khuẩn xấu nhân lên và gây nhiễm trùng hoặc viêm. Lợi khuẩn giúp cơ thể tiêu hóa thức ăn và cho phép cơ thể bạn hấp thụ các chất dinh dưỡng từ thực phẩm. Vi khuẩn tốt có thể sản xuất enzyme hoặc protein ức chế, hoặc thậm chí tiêu diệt vi khuẩn có hại. Các chủng men vi sinh cụ thể cũng kích thích hệ thống miễn dịch của cơ thể.

Để hiểu rõ hơn Cục Thông tin khoa học và công nghệ quốc gia xin giới thiệu một số bài nghiên cứu đã được xuất bản chính thức và các bài viết được chấp nhận đăng trên những cơ sở dữ liệu học thuật chính thống.

1. Springer

1. Tumor-targeted induction of intrinsic apoptosis in colon cancer cells by Lactobacillus plantarum and Lactobacillus rhamnosus strains
Mansour Amin, Tahereh Navidifar, Sholeh Saeb… in Molecular Biology Reports (2023)
https://link.springer.com/content/pdf/10.1007%2Fs11033-023-08445-x.pdf?pdf=core

2. The synergetic potential of Lactobacillus delbrueckii and Lactobacillus fermentum probiotics in alleviating the outcome of acute toxoplasmosis in mice
Tasneem M. Almallah, Safaa I. Khedr, Kholoud A. El Nouby… in Parasitology Research (2023)
https://link.springer.com/content/pdf/10.1007%2Fs00436-023-07787-6.pdf?pdf=core

3. Lactobacillus intestinalis/Lactobacillus rhamnosus protects against AFB1-induced liver damage: involvement of intestinal mucosal barrier
Yuanyuan Chen, Honglin Liu, Tianhui An, Qian Wu, Hongtao Zhang… in One Health Advances (2023)
https://link.springer.com/content/pdf/10.1186%2Fs44280-023-00023-x.pdf?pdf=core

4. Lactobacillus johnsonii CPN23 vis-à-vis Lactobacillus acidophilus NCDC15 Improves Gut Health, Intestinal Morphometry, and Histology in Weaned Wistar Rats
Sachin Kumar, Ashok Kumar Pattanaik… in Probiotics and Antimicrobial Proteins (2023)
https://link.springer.com/content/pdf/10.1007%2Fs12602-023-10063-9.pdf?pdf=core

5. Lactobacillus reuteri CCFM1175 and Lactobacillus paracasei CCFM1176 Could Prevent Capsaicin-Induced Ileal and Colonic Injuries
Bingyong Mao, Qunran Xiang, Xin Tang… in Probiotics and Antimicrobial Proteins (2023)
https://link.springer.com/content/pdf/10.1007%2Fs12602-023-10106-1.pdf?pdf=core

6. Synbiotic microencapsulation of Lactobacillus brevis and Lactobacillus delbrueckii subsp. lactis using oats/oats brans as prebiotic for enhanced storage stability
R. E. Kalpa, V. Sreejit, R. Preetha… in Journal of Food Science and Technology (2023)
https://link.springer.com/content/pdf/10.1007%2Fs13197-021-05240-z.pdf?pdf=core

7. In Vitro Assessment of Lactobacillus crispatus UBLCp01, Lactobacillus gasseri UBLG36, and Lactobacillus johnsonii UBLJ01 as a Potential Vaginal Probiotic Candidate
J. J. Ahire, S. Sahoo, M. S. Kashikar, A. Heerekar… in Probiotics and Antimicrobial Proteins (2023)
https://link.springer.com/content/pdf/10.1007%2Fs12602-021-09838-9.pdf?pdf=core

8. A Mixture of Multi-Strain Probiotics (Lactobacillus Rhamnosus, Lactobacillus Helveticus, and Lactobacillus Casei) had Anti-Inflammatory, Anti-Apoptotic, and Anti-Oxidative Effects in Oxidative Injuries Induced By Cadmium in Small Intestine and Lung
Shadi Dashtbanei, Zahra Keshtmand in Probiotics and Antimicrobial Proteins (2023)
https://link.springer.com/content/pdf/10.1007%2Fs12602-022-09946-0.pdf?pdf=core

9. Gut Lactobacillus and Probiotics Lactobacillus lactis/rhamnosis Ameliorate Liver Fibrosis in Prevention and Treatment
Sung Min Won, Na Young Lee, Ki-Kwang Oh, Haripriya Gupta… in Journal of Microbiology (2023)
https://link.springer.com/content/pdf/10.1007%2Fs12275-023-00014-y.pdf?pdf=core

10. Can vaginal lactobacillus suppositories help reduce urinary tract infections?
Poone S. Shoureshi, Clarissa Niino, Karyn S. Eilber in International Urogynecology Journal (2023)
https://link.springer.com/content/pdf/10.1007%2Fs00192-023-05568-4.pdf?pdf=core

11. Inhibitory effect and mechanism of Lactobacillus crispatus on cervical precancerous cells Ect1/E6E7 and screening of early warning factors
B. Wan, L. J. Wei, T. M. Tan, L. Qin, H. Wang in Infectious Agents and Cancer (2023)
https://link.springer.com/content/pdf/10.1186%2Fs13027-023-00483-1.pdf?pdf=core

12. A systematic review and meta-analysis: the therapeutic and preventive effect of Lactobacillus reuteri DSM 17,938 addition in children with diarrhea
Xiaoqi Sun, Juan Kong, Shuotong Zhu, Chengjiang Liu in BMC Gastroenterology (2023)
https://link.springer.com/content/pdf/10.1186%2Fs12876-023-02778-4.pdf?pdf=core

13. Changes in Intracellular and Extracellular Metabolites of Mixed Lactobacillus Strains Enhance Inhibition of Pathogenic Bacterial Growth and Lipopolysaccharide-Induced Alleviation of RAW264.7 Cellular Inflammation
Arong Wang, Chen Guan, Tieqi Wang, Guangqing Mu… in Probiotics and Antimicrobial Proteins (2023)
https://link.springer.com/content/pdf/10.1007%2Fs12602-023-10132-z.pdf?pdf=core

2.  Sciencedirect

1. Impact of Lactobacillus in the uterine microbiota on in vitro fertilization outcomes
Journal of Reproductive Immunology 22 August 2023
Daisuke Kadogami, Fuminori Kimura, Yoshiharu Morimoto
https://www.sciencedirect.com/science/article/pii/S0165037823003443/pdfft?md5=ffb4df7ab0938e4341111b84c3c675c3&pid=1-s2.0-S0165037823003443-main.pdf

2. Probiotic characteristics of Lactobacillus gasseri TF08-1: A cholesterol-lowering bacterium, isolated from human gut
Enzyme and Microbial Technology 7 June 2023
Mengmeng Wang, Tongyuan Hu, Yuanqiang Zou
https://www.sciencedirect.com/science/article/pii/S0141022923000844/pdfft?md5=1e77d9e5cdf332bd2c45b497b3c26950&pid=1-s2.0-S0141022923000844-main.pdf

3. Lactobacillus Plantarum NC8 and its metabolite acetate alleviate type 1 diabetes via inhibiting NLRP3
Microbial Pathogenesis 6 July 2023
Yuting Zhang, Yanning Li, Chunfeng Wang
https://www.sciencedirect.com/science/article/pii/S088240102300270X/pdfft?md5=284d38ec6aa8791db0b90fbe82319f23&pid=1-s2.0-S088240102300270X-main.pdf

4. Lactobacillus rhamnosus 76 alleviates airway inflammation in ovalbumin-allergic mice and improves mucus secretion by down-regulating STAT6/SPDEF pathway
Immunobiology 17 July 2023
Yangfan Hou, Shuping Zheng, Yun Liu
https://www.sciencedirect.com/science/article/pii/S017129852304514X/pdfft?md5=fab3d07009cfa82947afd09c039b85cb&pid=1-s2.0-S017129852304514X-main.pdf

5. Lactobacillus acidophilus regulates abnormal serotonin availability in experimental ulcerative colitis
Anaerobe 25 January 2023
Arzu Hizay, Kubra Dag, Nigar Keles-Celik
https://www.sciencedirect.com/science/article/pii/S1075996423000197/pdfft?md5=b3bb37cc97e7408b8fc62768bb76f2eb&pid=1-s2.0-S1075996423000197-main.pdf

6. Characterisation of dextran AP-27 produced by bee pollen isolate Lactobacillus kunkeei AP-27
Process Biochemistry 10 March 2023
Mustafa T. Yilmaz, Hümeyra İspirli, Enes Dertli
https://www.sciencedirect.com/science/article/pii/S1359511323000831/pdfft?md5=08d9e877101ff7fe64a9c3e74b068e00&pid=1-s2.0-S1359511323000831-main.pdf

7. Antitumor effect of invasive Lactobacillus plantarum delivering associated antigen gene sHSP between Trichinella spiralis and Lewis lung cancer cells
International Immunopharmacology 11 January 2023
Taotao Yue, Xichen Zhang, Nan Zhang
https://www.sciencedirect.com/science/article/pii/S1567576923000310/pdfft?md5=46adf4f9a8a3ea90a7fd2dfaff2d80c3&pid=1-s2.0-S1567576923000310-main.pdf

8. The effect of stabilized culture of Lactobacillus rhamnosus GCC-3 on gut and liver health, and anti-viral immunity of zebrafish
Fish & Shellfish Immunology 13 September 2023
Hui Liang, Yadong Xie, Zhigang Zhou
https://www.sciencedirect.com/science/article/pii/S1050464823005600/pdfft?md5=1e33c0c3f83bc34248b199184228e3c1&pid=1-s2.0-S1050464823005600-main.pdf

9. Probiotic potential of Lactobacillus sakei L-7 in regulating gut microbiota and metabolism
Microbiological Research 28 June 2023
Xuan Zou, Lei Pan, Ye Han
https://www.sciencedirect.com/science/article/pii/S0944501323001404/pdfft?md5=d7efa2bc1f3d1418ce43e0e5d116cf3a&pid=1-s2.0-S0944501323001404-main.pdf

10. The pH-dependent lactose metabolism of Lactobacillus delbrueckii subsp. bulgaricus: An integrative view through a mechanistic computational model
Journal of Biotechnology 10 August 2023
Tamara Bendig, Andreas Ulmer, Ana Sofia Figueiredo
https://www.sciencedirect.com/science/article/pii/S0168165623001414/pdfft?md5=5dd94e194158252c5d0f57ee075f436d&pid=1-s2.0-S0168165623001414-main.pdf

11. Lactobacillus rhamnosus reduces CD8+T cell mediated inflammation in patients with rheumatoid arthritis
Immunobiology 20 June 2023
Archana Tripathy, Nitish Swain, Bhawna Gupta
https://www.sciencedirect.com/science/article/pii/S0171298523010495/pdfft?md5=e6d56846556cec59518e1689c35028b9&pid=1-s2.0-S0171298523010495-main.pdf

12. A novel strategy for designing the antioxidant and adhesive bifunctional protein using the Lactobacillus strain-derived LPxTG motif structure
Process Biochemistry 3 February 2023
Shuyi Lu, Mingjuan Ou, Zhen Wu
https://www.sciencedirect.com/science/article/pii/S1359511323000314/pdfft?md5=863f1e8a2cdc111242e0096af0770c7b&pid=1-s2.0-S1359511323000314-main.pdf

13. Immunological effects of recombinant Lactobacillus casei expressing pilin MshB fused with cholera toxin B subunit adjuvant as an oral vaccine against Aeromonas veronii infection in crucian carp
Fish & Shellfish Immunology 5 July 2023
Hai-Chao Song, Yi-Xuan Yang, Wei Cong
https://www.sciencedirect.com/science/article/pii/S1050464823004205/pdfft?md5=f88451b8a7e9a79621297f3894a52c7d&pid=1-s2.0-S1050464823004205-main.pdf

14. Lactobacillus plantarum isolated from kefir enhances immune responses and survival of white shrimp (Penaeus vannamei) challenged with Vibrio alginolyticus
Fish & Shellfish Immunology 9 March 2023
Kuo-Chun Tseng, Huai-Ting Huang, Yu-Ju Lin
https://www.sciencedirect.com/science/article/pii/S105046482300147X/pdfft?md5=080b771c6bb98a0efd3b40694ca8f975&pid=1-s2.0-S105046482300147X-main.pdf

15. Symbiosis culture of probiotic Escherichia coli Nissle 1917 and Lactobacillus rhamnosus GG using lactate utilization protein YkgG
Process Biochemistry 16 January 2023
Yu-Chi Tseng, Chengfeng XueI-Son Ng
https://www.sciencedirect.com/science/article/pii/S135951132300017X/pdfft?md5=f98d38ef1a0e51b7bf7b7b8e48a3fa4b&pid=1-s2.0-S135951132300017X-main.pdf

16. Efficacy of a recombinant Lactobacillus plantarum Lp-pPG-Malt as an oral vaccine candidate against Aeromonas hydrophila infection in crucian carp
Fish & Shellfish Immunology 7 April 2023
Qing Yang, Bin-Tong Yang, Wei Cong
https://www.sciencedirect.com/science/article/pii/S1050464823002231/pdfft?md5=2e3769896f66ece6ca7fb0ed5405c866&pid=1-s2.0-S1050464823002231-main.pdf

17. Construction of a Lactobacillus plantarum-based claudin-3 targeting delivery system for the development of vaccines against Eimeria tenella
Vaccine 14 December 2022
Lingyu Sun, Ningning Zhao, Xiaomin Zhao
https://www.sciencedirect.com/science/article/pii/S0264410X22015286/pdfft?md5=e55ad857f4c2ac88c14929fcda8b1917&pid=1-s2.0-S0264410X22015286-main.pdf

18. Investigating the effect of the probiotic Lactobacillus plantarum and the prebiotic fructooligosaccharides on Pseudomonas aeruginosa metabolome, virulence factors and biofilm formation as potential quorum sensing inhibitors
Microbial Pathogenesis 5 March 2023
Bayan A. Al-Saafin, Amal G. Al-Bakri, Lina A. Dahabiyeh
https://www.sciencedirect.com/science/article/pii/S0882401023000906/pdfft?md5=b88b21640fb948c77e0c73a4af5d149d&pid=1-s2.0-S0882401023000906-main.pdf

19. Immunization effect of recombinant Lactobacillus casei displaying Aeromonas veronii Aha1 with an LTB adjuvant in carp
Fish & Shellfish Immunology 20 March 2023
Xue Jiao, Dong-Xing Zhang, Ai-Dong Qian
https://www.sciencedirect.com/science/article/pii/S1050464823001468/pdfft?md5=682c0906296f41cdaa65b6b54a7e74c2&pid=1-s2.0-S1050464823001468-main.pdf

20. Oral vaccination with recombinant Lactobacillus casei with surface displayed OmpK fused to CTB as an adjuvant against Vibrio mimicus infection in Carassius auratus
Fish & Shellfish Immunology 1 March 2023
Hong-Jin Li, Bin-Tong Yang, Yuan-Huan Kang
https://www.sciencedirect.com/science/article/pii/S1050464823001456/pdfft?md5=50083eb9f2f9842b54141cd4fe848491&pid=1-s2.0-S1050464823001456-main.pdf

21. Translocation of vaginal and cervical low-abundance non-Lactobacillus bacteria notably associate with endometriosis: A pilot study
Microbial Pathogenesis 15 August 2023
Qing Yang, Yinan Wang, Ruifang Wu
https://www.sciencedirect.com/science/article/pii/S088240102300342X/pdfft?md5=f0225fb31a9823d5f29928c19295843c&pid=1-s2.0-S088240102300342X-main.pdf

22. Assessing the protection mechanisms against Enterobacter aerogenes by analyzing aggregation, adherence, antagonistic activity, and safety properties of potentially probiotic strain Lactobacillus brevis G145
Microbial Pathogenesis 25 May 2023
Hassan Barzegar,  Behrooz Alizadeh Behbahani, Mitra Ghodsi Sheikhjan
https://www.sciencedirect.com/science/article/pii/S0882401023002085/pdfft?md5=9a76fe0d7f67de374a411e92e7752767&pid=1-s2.0-S0882401023002085-main.pdf

23. Fermentation profile, aerobic stability, and microbial community dynamics of corn straw ensiled with Lactobacillus buchneri PC-C1 and Lactobacillus plantarum PC1-1
Microbiological Research 14 February 2023
Charles Obinwanne Okoye, Yanfang Wu, Jianxiong Jiang
https://www.sciencedirect.com/science/article/pii/S0944501323000319/pdfft?md5=3fd6f72b6d4fb80aa18500f1f1cba133&pid=1-s2.0-S0944501323000319-main.pdf

24. Potential of infrared drying and cell-protective agent efficiency on survival of Lactobacillus plantarum probiotic in fermented soybean meal
Biocatalysis and Agricultural Biotechnology 12 September 2023
Atsadawut Areesirisuk, Apinun Wanlapa, Chiu-Hsia Chiu
https://www.sciencedirect.com/science/article/pii/S187881812300244X/pdfft?md5=5878b2121fe898971392094ff18c80e2&pid=1-s2.0-S187881812300244X-main.pdf

25. The interaction among Kluyveromyces marxianus G-Y4, Lacticaseibacillus paracasei GL1, and Lactobacillus helveticus SNA12 and signaling molecule AI-2 participate in the formation of biofilm
Food Microbiology 25 August 2023
Xiaomeng Wang, Kai Ma, Wei Li
https://www.sciencedirect.com/science/article/pii/S0740002023001569/pdfft?md5=84cf2fa77bbb655be3e7d281d1a62d82&pid=1-s2.0-S0740002023001569-main.pdf

26. Immunomodulation in the intestinal mucosa of mice supplemented with Lactobacillus rhamnosus (ATCC 7469) and infected with Toxocara canis
Immunobiology 24 February 2023
Micaele Quintana de Moura, Carolina Netto de Oliveira da Cunha, Carlos James Scaini
https://www.sciencedirect.com/science/article/pii/S017129852300027X/pdfft?md5=ad9cd12ca913765bb646574447280155&pid=1-s2.0-S017129852300027X-main.pdf

27. Characterization of a processive inulosucrase from Lactobacillus mulieris for efficient biosynthesis of high-molecular-weight inulin
Enzyme and Microbial Technology 15 December 2022
Shuqi Zhang, Dawei Ni, Wanmeng Mu
https://www.sciencedirect.com/science/article/pii/S0141022922002058/pdfft?md5=24eab5f6f5165792452430de66fb00be&pid=1-s2.0-S0141022922002058-main.pdf

28. The activation of CaN/NFAT signaling pathway in macrophages aggravated Lactobacillus casei cell wall extract-induced Kawasaki disease vasculitis
Cytokine 22 July 2023
Yameng Sun, Yijing Tao, Fangqi Gong
https://www.sciencedirect.com/science/article/pii/S1043466623001825/pdfft?md5=aa1b591aec8fccb608b722677540c8c5&pid=1-s2.0-S1043466623001825-main.pdf

29. Dietary Lactobacillus helveticus and Gum Arabic improves growth indices, digestive enzyme activities, intestinal microbiota, innate immunological parameters, antioxidant capacity, and disease resistance in common carp
Fish & Shellfish Immunology 28 February 2023
Morteza Yousefi, Mehdi Naderi Farsani, Mahdieh Raeeszadeh
https://www.sciencedirect.com/science/article/pii/S1050464823001389/pdfft?md5=beaa4067aa2ef115e5841a5cf73c99c8&pid=1-s2.0-S1050464823001389-main.pdf

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